ABSTRACT
This chapter discusses the encapsulation of the model drug dipyridamole with Polyhydroxy butyrate (PHB). Biodegradable polymers are a rapidly emerging field that holds great promise for revolutionizing drug delivery systems, tissue engineering applications, and biomedical sensors. Natural polymers, proteins and polysaccharides, have advantages over their synthetic counterparts and are used for various biomedical applications due to their biocompatibility and non-immunogenic properties. Bacteria can synthesize a wide range of biopolymers that serve diverse biological functions and have material properties suitable for numerous industrial and medical applications. Studies on Cupriavidus necator are most extensive due to its ability to accumulate large amounts of PHB from simple carbon sources: for example, glucose, fructose, and acetic acid. The oil water emulsion solvent evaporation method is normally adopted for the preparation of dipyridamole-loaded PHB, as both the polymer and the drug were found to be soluble in the organic phase.
