ABSTRACT
This chapter discusses the precise roles of oxidative stress and Role of Oxidative Stress (ROS) in the pathogenesis of several neurological diseases are elucidated. Oxidative stress is one of the leading hypothesis regarding the pathogenesis of these neurological disorders. Oxidative stress is induced by various factors that disturb intracellular oxidant and antioxidant homeostasis in the brain cells and ultimately affects normal brain functions. Neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis are also common with advancing age where oxidative stress plays an important role in disease progression. Antioxidants, antioxidant enzymes, and dietary supplements have been shown to prevent oxidative stress and mitochondrial dysfunctions in PD patients. Oxidative stress response is mainly controlled by transcription factor nuclear factor. Multiple lines of evidence have shown strong insinuations that oxidative stress plays an important role in the pathogenesis of various neurological diseases. In this chapter, precise roles of oxidative stress and ROS in the pathogenesis of several neurological diseases are elucidated.
