ABSTRACT
“Particle engineering” is a term coined to encompass means of producing particles having a defined morphology, particle size distribution, and composition. Generally, particle engineering is associated with particle size reduction techniques, such as media milling and homogenization, and micro- or nanoparticle formation techniques, such as spray-drying, are mostly well established. Particle engineering combines elements of many others, including chemistry, pharmaceutics, colloid science, mass and heat transfer, aerosol and powder science, and solid-state physics. The emerging technology such as nanotechnology whose goal is to control individual atoms and molecules to create material that has a size of only a few nanometers. Nanotechnology provides methods for targeting and releasing therapeutic compounds in very defined regions. Similarly, 3-D printing, machine learning, and artificial intelligence (AI) are promising potentials for precision and personalized medicine in the coming years. Other emerging particle engineering approaches include supercritical fluid technology, co-crystallization, electrospinning, and microbiome-based therapeutics. All these emerging engineering technologies will change the way we develop and manufacture pharmaceutical dosage forms in the coming years.
