This chapter provides preliminary steps towards a more integrated and holistic approach to understanding and creating healthy settings for animals, humans, and the environment. We highlighted the importance of the spatial perspective in health, outlined some of its shortcomings when applied in a strictly spatial-epidemiological sense, and followed up with some proposals from health geography that might be applied in a One Health context. Much work remains to be done to realize a health settings framework for multi-species health, but we can clearly see the emergent path forward is highly collaborative, reliant on engagement with communities, and is mixed methods in nature. Geography can play a key role in exploring and mapping the Eco-Healthscape.