ABSTRACT
The influence of the synthetic antioxidant potassium salt of phenosan (potassium phenosan) in a wide range of concentrations, the exposure of gamma radiation at a dose of 15 cGy and their combined effect on the activity of aldolase and lactate dehydrogenase (LDH) in the cytoplasm, microsomes, and synaptosomes of the mice brain at different duration after the cessation of, action, as well as the structural state of the membranes and the composition of the mice, brain lipids have been studied. Maintaining the changes in the activity of enzymes and microviscosity of membranes of the brain structures after the termination of chronic γ-irradiation of mice at a dose of 1.2 cGy is shown for a long time.
Different sensitivity and ability to normalize of the studied parameters depending on the dose of both a substance and radiation, as well as on the duration after action have been revealed. In the early period after a combined action of the preparation and irradiation, an increase of the microviscosity of the probe localized in the surface layer of the lipid phase of the brain subcellular structures is accompanied by an increase in the ratio of the main fractions of phospholipids (PL) in the mice brain.
The set of the obtained data testifies to a high sensitivity of the brain structures to the effects of potassium phenosan and low-intensity radiation at 210the low doses, as well as to the absence of a linear dependence on the dose of the substance, which results in a complex nature of changes in the functional activity of the brain.
