ABSTRACT
Ester prodrugs facilitated permeation of ketobemidone across porcine buccal mucosa and prominently enhanced lipophilicity and susceptibility to undergo transformation via mucosal esterases to parent drug. The majority of drugs that are presently utilized for cancer therapy have limitations, for example, resistance induction or lower biological half-life which is responsible for reducing their therapeutic effectiveness. Adefovir dipifoxil is a pivaloyloxymethyl ester prodrug of nucleosidic reverse transcriptase inhibitor, adefovir. The active drug dabigatran indicated in thromboembolism acute coronary syndrome is highly polar. Ketorolac, a non-selective cyclooxygenase-inhibitor, was converted into its ester prodrug by linking it with piperazinalkyl promoiety with a goal of improved topical penetration. Naproxen is one of the most potent nonsteroidal anti-inflammatory drugs which is generally used for treating the rheumatic diseases and other such painful disorders. Prodrugs have now become inherent members of the drug discovery and development process.
