ABSTRACT

This paper described the biosynthesis of silver nanoparticles (AgNPs) using Ventilago maderaspatana leaves, and explained their efficiency of antidiabetic activity. Biosynthesized Ag Nps were characterized by UV-Vis Spectroscope, FT-IR, transmission electron microscope (TEM), SEM, and EDAX. UV-Visible spectrum showed an absorption peak at nanoscale range of 431 nm which confirmed that the size of Ag particles are found at nanoscale range. FT-IR spectrum revealed the secondary metabolites found in the leaf extract responsibilities for the formation of nanoparticles (NPs). SEM study showed ball-shaped Ag Nps. TEM study revealed that size of biosynthesized AgNPs were found between the nanoscales of 10 to 50 nanometer. Results of the EDAX confirm the presence of silver in the biosynthesized NPs. Further, biosynthesized AgNPs effectively reduced the increased level of blood glucose, HbA1C, total protein and albumin, and also restored level of serum insulin on STZ induced diabetic albino rats. Thus, V. maderaspatana leaf, extract may be useful for eco-friendly synthesis of Ag NPs and they can be used for antidiabetic drug preparation.