ABSTRACT
Over 20 years, researchers have been focusing on identifying cancer signaling pathways and associated protein targets to discover inhibitors of therapeutic importance with enhanced selectivity, efficacy, and reduced toxicity. Protein kinases represent such molecular targets and remarkable efforts have been carried out in developing drugs that influence the action of pathogenic kinases, and clinical studies performed so far have shown the positive effects of kinase inhibitors to treat cancer. In this chapter, the structural features of different kinases, their mechanism of action, types of inhibitors based on such binding mechanisms and the current state of the art have been discussed.
