ABSTRACT
the last two decades, several types of tissue adhesives have been developed to complement or substitute for sutures in surgical procedures. Some of them (e.g., cyanoacrylate derivatives) are of synthetic origin. They have high adhesive strength but poor biodegradable characteristics that often cause cytotoxicity and tissue necrosis. Other adhesives are of biological origin. Fibrin glues, for example, are products comprised of the purified plasma proteins that constitute the fibrin network. Biocol was registered in France in 1984 and is undergoing registration in other countries. More than 350 liters of this fibrin glue have already been used in clinics in France corresponding to more than 100,000 clinical applications. The manufacturing process has a European and a US patent issued. This fibrin glue preparation, due to its unique composition, represents a convenient and reproducible means of achieving effective hemostasis and healing without side effects.
