ABSTRACT
Ageing leads to wear and tear of skin and internal organs due to chronic and repeated exposure to reactive oxygen and nitrogen species (RONS family), resulting in oxidative stress-related degenerative disorders. In addition, the protective wall of cellular defence mechanisms weakens with advancing age. Apocarotenoids as potent antioxidants and anti-inflammatory agents show tremendous potential as anti-ageing agents by targeting the RONS family. The protective role of apocarotenoids like bixin, crocin, crocetin, safranal, apolycopenoid, and β apocarotenals in cellular signalling and strengthening the exhausted cellular defence mechanisms has been discussed. The shielding effect of apocarotenoids against deleterious effects of ageing like photo-ageing, deterioration of vision, activation of proinflammatory mechanisms, progression of cancer, neurological degeneration, impaired metabolism of macronutrients, and vascular remodelling has been highlighted in the chapter.
