ABSTRACT
The International Society of Sexual Medicine (ISSM) has provided some further quantification as an aid to diagnosis. A key component both of the definition and diagnosis of Premature Ejaculation (PE) has been the assessment of the intravaginal ejaculatory latency time (IELT), first described by the late Marcel Waldinger in 1994. The lack of proven animal models of both the ejaculatory reflex and the pathophysiology of PE. Fortacin is a mixture of prilocaine and lidocaine in base form at a ratio when combined, forming a eutectic-like mixture. The eutectic properties were required for the development of a metered dose spray formulation. The salt forms are readily soluble in aqueous solution and so are suitable for the preparation of injectable systemic preparations; but as they are not lipid soluble, they do not readily penetrate epithelial surfaces and as such are not suitable for topical delivery into and through the glans penis.
