This chapter summarizes selective advances of stimuli-response nanomaterials and consists of two sections: responsive nanoparticles and responsive nanowires and nanotubes. Stimuli-responsive nanomaterials play an important role in modern materials’ design and offer numerous opportunities for future technological advances. Numerous studies published as early as 1950s have reported the synthesis of colloidal nanomaterials, which primarily focused on spherical colloidal nanoparticles known as latexes. Formation of anisotropic stimuli-responsive nanomaterials is accomplished by molecular design of copolymer blocks that in specific environments will self-assemble to form anisotropic shapes. Multilayers of nanotube-forming phospholipid templates that consist of thermally responsive polymers can serve as templates with tunable diameter and wall thickness. A general method to fabricate these nanotubules is to incorporate polymerizable thermal-responsive monomers into the hydrophobic area of phospholipid template.