ABSTRACT
The central nervous system controls much of the body, including significant activities such as keeping the heart beating and breathing. Serotonin-specific reuptake inhibitors or selective serotonin re-uptake inhibitors are a family of organic entities usually employed as anti-depressants for the medication of numerous depression related disorders. The interesting chiral structure combined with an impressive pharmacologically important profile attracted chemists to develop facile and concise total synthetic approaches from economic and available materials to access (S)-duloxetine 1 and structural analogues. The enzyme-catalyzed mediated reactions concerning the application of whole cells or pure enzymes. The racemic azidoacetates are synthesized in four steps, starting with Friedel-Crafts acylation on thiophene entity 6 by 3-chloropropanoyl chloride to furnish the ketone 7.
