This chapter focuses on presenting new strategies for local regeneration therapy of the dentin-pulp complex; such a process is mediated by odontoblast and relates to preservation of pulp vitality, and clinical management of deep caries, necrotic pulp with apical periodontitis necrotic and immature permanent teeth. It helps the reader understand factors involved in repairing of the damaged pulp. The chapter also reviews the current knowledge of the potential future developments. The main goal of regenerative endodontics is the use of biologic-based procedures to arrest the disease process, preventing its recurrence while favoring the repair or replacement of damaged structures of the dentin-pulp complex. Complete regeneration of pulp-dentin complex in empty root canal space with all laboratory or clinical approaches has not been achieved as yet. All current approaches of pulp regeneration are still in the development phase.