The purposes of this chapter are to (a) assess the overall state of participatory design practices in autism research and reflect how these findings relate to human systems engineering (HSE), (b) explore whether participatory practices are meeting the needs of participant communities, and (c) conceptualize waypoints for ethical and transformative research practices in HSE and beyond. This chapter is meant to be an intervention—an accounting for our duty to uphold the principles of Respect for Persons, Beneficence, and Justice. HSE cannot enact social justice through the deployment of technology itself. Justice must be present throughout the very action of design.