ABSTRACT
Flavonoids are an important class of secondary metabolites. During natural synthesis of flavonoids, their basic skeleton gets modified by the different type of chemical group. Various enzymes are involved in this type of modification. Structure-function relationship has been reported for their biological activity. Methylation is a type of natural modification in flavonoids. Methylation of hydroxyl group, where methyl group attached with the oxygen gives rise to O-methylated flavonoids. On the other hand, when methylation occurs at carbon of flavonoid basic structure, it results into synthesis of C-methylated flavonoids. Methylation of flavonoid is known for their various biological activities and has a role in their digestion process also. Metastasis with invasion is a multistep process which accounts for a number of cancer- associated deaths worldwide. This chapter discusses the chemistry and biological activities of methylated flavonoids. We will also discuss the in silico potential of these flavonoids as an anti-metastasis agent.
