ABSTRACT
Bone tissue has the capacity to adapt to its functional environment through alterations in bone remodeling orchestrated by the cells of the skeleton—the osteoblasts, osteocytes, and osteoclasts. To fulfill this capacity, those cells responsible for bone remodeling both perceive and respond to the mechanical environment. In this way, mechanical forces exert regulatory control over skeletal morphology, and ultimately produce a skeleton that can withstand daily functional use. Understanding how the cells of the skeleton convert mechanical signals into a programmed biological response has been the goal of our laboratory.
