ABSTRACT
The domesticated silk worm, Bombyx mori is the main target of the scientific study because of its socioeconomic importance. Here, we highlighted that essential nutrients obtained during larval stage, but needed by the non- feeding pupal stage, must be sequestered and carried across stages until they are mobilized in the mature silkworm. The storage protein (smart proteins) and other physiological vital proteins/enzymes appear to be special adaptations in insect molting, metamorphosis, and cyclic reproduction. We therefore advocate for an increased focus on the molecular structure-function relationship of physiologically important proteins (SP, Vg, Lipophorin-30kDa, ApoLp-III, Feriitin and Bombyrin) for silkworm biology that will help in better understanding insect molecular biology. We conclude that this molecular evolution and bioinformatics approach of key proteins likely to contribute invaluable molecular structure and specifically how they regulate cellular regulation and homeostasis.
