Obesity is a disorder comprising of excess body fat which is associated with an increase in health problems. Nanocarriers are now being analyzed for their functions in drug delivery and their exceptional characteristics validate their potential use in chemotherapy and diabetes. Polysaccharide-based nanoparticles are receiving significant attention as they are considered one of the most favorable nanoparticular delivery systems because of their innate unique potentials. Nano drug molecules bind to proteins found in the lining of the blood vessels that surround adipose tissue or bind to receptors on the outer surface of the adipose tissue and burn it. Nanotechnology-based drug delivery into obese adipose tissue will enhance opportunity in the pharmaceutical industry. In obesity, expansion of adipose tissue and its transformation depends on the active growth of new blood vessels; hence, angiogenesis presents a prospective target for the treatment of obesity associated morbidity.