ABSTRACT
The neuropathological hallmarks of Alzheimer's disease include extracellular amyloid B, senile plaques and intracellular neurofibrillary tangles. The neuropathological hallmarks of Alzheimer's disease include extracellular amyloid B, senile plaques and intracellular neurofibrillary tangles. The gut microbiota comprises of a complex community of microorganisms that reside in our gastrointestinal ecosystem, alterations to this complex fragile ecosystem influence not only various gastrointestinal disorders but also central nervous system disorders such as Alzheimer's disease. The small numbers of studies that have explored this area tend to demonstrate that probiotics can not only affect microbiota but can also influence cognitive behaviour or Alzheimer's related pathogenesis. Alzheimer's disease accounts for 60 to 80% of all dementia. Dementia is a chronic disease of aging characterized by the progression of cognitive decline that interferes with every aspect of the person's independent function. Breast fed infants tend to harbour Bifidobacteria in their gastrointestinal tract whereas bottle-fed infants tend to have a much more diverse population of microbiota.
