ABSTRACT
Surface-enhanced Raman spectroscopy (SERS) is a powerful analytical tool for the identification of biomolecules from nucleic acids to proteins, and imaging of various materials from membranes to tissues, thus exhibiting strong potential for biological exploration. As a promising technology, SERS has the potential to inform on the composition and structure of bio-membrane for better elucidation of its function. In this chapter we will investigate strategies based on SERS to study proteins, lipids, and oligosaccharides, the primary components of bio-membrane, their distribution and dynamics by SERS. We will also explore a tip-enhanced Raman scattering (TERS) technique for high resolution spectroscopy and imaging.
