ABSTRACT
Neem has been well known as herbal medicine because of it is beneficial properties, such as antihyperglycemic, antifungal, spermicide especially in herbal contraception. The aim of this study was to observe antifertility and morphometry of reproductive organs of male mice, such as fertility and weight of testis and epididymides. The mice were orally administered the aqueous neem seed extract with doses of 0.00, 0.25, and 0.50 mg/kg body weight for 36 days and then treatment was stopped for 36 days. This experiment used a completely randomized design and data was analyzed by Tukey’s tests. The results showed a reduction in fertility, and reduce testicular weight, was reversible, but did not decrease testicular morphometry and epididymides. However, fertility and reversibility of reproductive organs gave significantly different (p < 0.05). After 36 days of withdrawal of treatment, the reproductive organs of male mice recovered to the control group. Morphometric results of the testis, and epididymides of treated mice were not significantly different (p > 0.05). Conclusion, aqueous neem seed extract caused antifertility and reversible alterations in the male reproductive organs of mice, and has the potential to be male contraceptive.
