ABSTRACT
Two bromonaphthyl chalcones (Compounds 1a and 1b) and four bromonaphthyl pyrazolines (Compounds 2a, 3a, 2b and 3b) have been docked to evaluate their potency as anti-inflammatory agents. The molecular docking study showed that Compounds 2a and 3a have good potency as anti-inflammatory agents. Compounds 2a and 3a have been synthesized under microwave irradiation via a two-step reaction. The structures of both compounds were confirmed on the basis of spectroscopic data, including Ultraviolet-Visible (UV-Vis), Fourier-Transform Infrared Spectroscopy (FTIR), High-Resolution Mass Spectrometry (HRMS), and 1H and 13C Nuclear Magnetic Resonance (NMR). The in vivo evaluation showed that the oral administration of Compounds 2a and 3a at dosages of 25, 50 and 100 mg/kg of body weight showed a good ability to significantly (p < 0.05) reduce inflammation of a carrageenan-induced paw edema in male albino mice (Mus musculus L.), compared to the negative control. In addition, the administration of Compounds 2a and 3a at dosages of 25, 50 and 100 mg/kg of body weight did not show a significant difference in ability to inhibit the edema volume (p > 0.05) when compared to the anti-inflammatory drug, diclofenac sodium.
