ABSTRACT
The prevalence of neurological disorders and its untreatable nature owing to the omnipotent presence of the blood-brain barrier has posed a serious problem in the medical fraternity owing to the lack of efficient drug-delivery systems for efficient treatment of these ailments. Thus, with a view to mitigate these problems, increased research is going on to target the potent molecules at the site of action, that is, the brain and central nervous system. The advancements of nanotechnology have provided a huge respite to these problem owing to their nanodimensions, allowing to treat these ailments with much more efficiency than previously possible by conventional routes. In our chapter, we have highlighted with of those facts as well as the functional advantages that each of these nanoparticles, namely polymeric and lipid nanoparticles, provide owing to their chemical structure and composition. We also discussed various functional properties and synthesis techniques for each of these nanoparticles and possible improvements with regards to the current state of research in this and allied fields of treatment. We also highlighted the possible physiological hurdles that we as formulation scientist face while designing a particular formulation for targeted delivery of drugs to the brain, so that the reader can understand and comprehend the need for such drastic and complicated technological applications.
