ABSTRACT
Wound healing is a normal biological process that the body carries out to repair wounds as a response to tissue injury and it is interdependent on the cellular and biochemical stages. The wound healing process is achieved through four precisely programmed and highly overlapping phases: Hemostasis, Defensive/Inflammatory, Proliferative, and Maturation/Remodeling. Medicinal plants can promote wound healing effects by different mechanisms such as by modulation in wound healing, promoting blood clotting, fighting against infections and accelerating wound healing including improving collagen deposition, increasing fibroblasts and fibrocytes, and so forth. Nephelium lappaceum also known as rambutan is a seasonal tropical fruit tree species commonly grown in Southeast Asia and belongs to the same family as lychee and longan, the Sapindaceae. In Sarawak, the leaves are boiled for a short time and the juice squeezed from the boiled leaves is dripped into the wound or cut. Morinda citrifolia extract improves wound healing by decreasing wound size and time for epithelialization.
