ABSTRACT
Targeted radionuclide therapy (RNT) consists of biologically selective irradiation of malignant cells by means of radionuclide labelled tumour-seeking molecules or devices. A variety of radionuclides, emitting nuclear particles with a range of path lengths from nanometres to millimetres, and novel clinical strategies are currently used. Basic aspect of radiobiology adapted for RNT are illustrated. The ‘Rs’ of radiobiology, the Linear Quadratic model and the EQDX Formalism are presented. The proposed dose-effect relationships in terms of Tumour control probability (TCP) and Normal Tissue Control Probability (NTCP) are reported illustrating the radiobiological parameters and their uncertainties. Finally, the basic definition of the abscopal effect is reported
