ABSTRACT
Two models of tumor escape from an active anti-tumor response have been developed. The models describe cell populations which exhibit random lifelengths distributed in accordance with a gamma distribution. They have been simulated using Monte Carlo techniques which model the lifelength as a series of maturation chambers each distributed in accordance with an exponential distribution. The malignantly transformed cells are characterized by three binary variables: Escape Route, Target Structure Stability, and End Susceptibility. The simulated results show that the ability of a tumor to escape depends on the activity generated by the immune system in the anti-tumor response. However, tumor escape is also a function of tumor cell type.
