This chapter discusses the major sex hormone in a woman's body which is estrogen, produced mainly by the ovaries. The critical pain-control hormones that are produced in glands outside the central nervous system are cortisol, pregnenolone, dehydroepiandrosterone, progesterone, testosterone, estrogen, and thyroid. Tennant, in his landmark article, examines the major pain-control mechanisms of each sex hormones in the steroidogenic pathway. The study showed that testosterone applied transdermally to individuals with fibromyalgia was an effective therapy for chronic pain control. Consider replacing these hormones before starting narcotic pain control medications including therapies for cortisol dysfunction. Testosterone is the main sex hormone produced by the male. It is produced by the Leydig cells in the testes, and a small amount is also produced in the adrenal glands.