ABSTRACT
In the inflammatory process, monocytes leave the blood and enter the tissue at the site of inflammation as part of the cellular infiltrate. The tissue endothelial cells in inflammation express adhesion molecules to which monocytes adhere, then they penetrate through the endothelium into the tissue along a gradient of inflammation signals. The metabolites of the arachidonic acid cascade (Fig. 1), like leukotriene, prostaglandin, as well as oxygen radicals, play an important role.
