ABSTRACT

The interfacial behavior of proteins is of importance in biochemical and biophysical processes, such as complement activation, thrombus formation, initial stages of arteriosclerosis, dental pellicle formation, etc., and a host of biomedical applications, such as intravenous drug delivery, solid-phase diagnostics, extracorporeal therapy, biomaterials, biosensors, biotechnical separation methods, biofouling, dental implants, etc. Not surprisingly, therefore, substantial work has been devoted to understanding the behavior of proteins at interfaces and the interplay between factors determining this interfacial behavior.