ABSTRACT
Although age related and progressive cognitive decline has been known since antiquity, Dr. Alois Alzheimer reported the five-year clinical course of a 51-year-old woman with progressive dementia and autopsy findings of neuronal loss, neurofibrillary tangles, and miliary amyloid plaques upon light microscopic examination of Bielshowsky silver-stained brain sections. Thus, Dr. Alzheimer was the first to suggest a link, perhaps causal, between a dementing disease and these abnormal proteinaceous aggregates in brain (1).
