ABSTRACT
In Oral Squamous Cell Carcinoma (OSCC), the risk assessment, probability of developing locoregional recurrence and metastatic deposit, and the tailor-made post-operative treatment strategies for each patient are recommended by the multidisciplinary team (MDT) mainly on the basis of TNM staging and histopathological report. So far, there is no molecular biomarker to classify subgroups more accurately in OSCC. Earlier studies revealed that the level of mature miR-100 expression is significantly altered and frequently associated with poor prognosis suggesting that miR-100 can be a potential biomarker candidate in OSCC. In the present study, total 40 patients with newly diagnosed OSCC were selected and EDTA whole blood (onset of surgery), histopathology, follow-up outcome data were collected. We measured cell-free mature miR-100-5p expression through qRT-PCR using plasma samples from each patient. Here, we explored and tried to correlate their functional relationship between the pathological conditions and the level of cell-free mature miR-100-5p expression in plasma with respect to disease recurrence and metastasis in patients with OSCC.
