ABSTRACT
The effect of physical stimuli on bone tissue is well established; bone cells respond to both mechanical and electrical forces. The effects of mechanical forces on bone tissue are linked to the mineralized component of the bone or to the vital one. As pharmacodynamics for drug development, Physical dynamics is the basis of biophysical stimulation of bone healing. Many researches have focused on the effect of biophysical stimulation on cell proliferation and synthesis of extracellular bone matrix. Congenital pseudoarthrosis is a rare disease; it occurs most commonly in the tibia of infants with stigmata of neurofibromatosis, particularly cafe-au-lait spots, or a family history of neurofibromatosis. The use of pulsed electromagnetic fields (PEMF) stimulation favored rapid healing of the osteotomic line and, in the case of femur osteotomy, an early mineralization of the bone callus. Positive results have been widely reported on the use of PEMF to promote bone healing.
