ABSTRACT
This paper discusses atom economy, applications in combinatorial chemistry, and diversity-oriented synthesis. Such heterocycles show chiral center, which have a wide scope of pharmacological properties including antiviral, antitumor, antibacterial, and anti-inflammatory activities. The pyrimidine ring gives good antimicrobial activity and potent antitubercular activity. Recently, functionalized dihydropyrimidin (DHPM) analogs have emerged as active antihypertensive agents. Thus, the synthesis of these heterocyclic compounds is very important in present areas of study. The search for more suitable preparation of dihydropyrimidinone continues today also. The first protocol to prepare the compounds of this type was presented by Biginelli in 1893 and it involved a three-component, one-pot condensation. A major drawback to Biginelli’s original was poor-to-moderate yields. This review explains collectively the synthesis of dihydropyrimidinones in various conditions using a variety of catalysts and some solid supported catalysts. This review also gives an application of Biginelli’s reaction and its modifications and enantioselective synthesis.
