This chapter ties certain health issues seen in food animals to soil, plant, and human health concerns involving the overuse of glyphosate. This overuse occurs both from glyphosate’s use on genetically engineered (GE) crops and from its use as a drying agent (“harvest aid”) for non–Roundup Ready crops. The lack of public funding for the agricultural sciences and the concurrent lack of scientists who are truly knowledgeable generalists are of concern for agricultural sustainability. The generalists are needed to give direction to the specialists our current educational system produces and to formulate long-term public agricultural policy. Now that we are beginning to recognize the influences of epigenetics and fetal programing, and to acknowledge the importance of biodiversity, society needs a renewed environmental ethos to balance and direct our use of genomics. Today’s complicated questions require multiple repetitions of new stand-alone studies. These studies should be superior to our often overreliance on metanalysis—the process of using many previous studies and declaring the majority opinion as the correct science. It is important that the precautionary principle is fully honored in our age of endocrine-disrupting chemicals, especially when they are used in various combinations.