ABSTRACT
Seborrheic keratosis (SK), also known as seborrheic wart, senile wart or basal cell papilloma, is the most common benign epidermal tumor of middle-aged or elderly people. SKs of the genital area typically occur on the keratinized skin. In early developmental stages, SKs usually present as one or more well-demarcated, oval or round, skin-colored/brown/gray, flat macules, which then evolve into flat-topped, papules and plaques or polypoidal lesions. SKs in the genital area are uncommonly mistaken for human papillomavirus-associated lesions, but the clinical differential diagnosis of SK also includes malignant melanoma, melanocytic nevus, verruca vulgaris, acrochordons, epidermal nevus, actinic keratoses, extramammary Paget's disease, pigmented Bowen's disease, pigmented basal cell carcinomas, and squamous cell carcinomas. SKs are usually recognized on clinical grounds according to their morphology, even though diagnosis may sometimes be challenging when classical clinical features are missing, the especially on genitalia.
