ABSTRACT
Invasive squamous cell carcinoma (SCC) is a high-grade neoplasia originating from cutaneous squamous cells, often following a progressive model from healthy skin cells to progressively more malignant entities. The overall 5-year survival rate for genital SCC is 71% in women and 67% in men. Genital SCC can be put in differential diagnosis with a plethora of different disorders, both inflammatory and neoplastic, such as SCC in situ, basal cell carcinoma, amelanotic melanoma, extramammary Paget's disease and lichen sclerosus. Dermoscopically, SCC shows no pathognomonic features, and its identification is based mainly on the presence of altered and chaotic patterns, predominance of white color, and polymorphous vessels with irregular distribution. Linear-irregular vessels, mainly located centrally within the lesion, and hairpin vessels, more peripherally, are quite typical in the described cases of invasive genital SCC and allow to differentiate it from other entities.
