ABSTRACT
Verbena carolina is used as a decoction in Mexican folk medicine (MFM) with applications vs. digestive problems and for dermatological infections. This work reports high-pressure liquid chromatography analysis, and extracts and isolated-compounds free radical scavenging capacity, which antimicrobial analyses vs. the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Salmonella typhi, and the fungi Candida albicans, Trichophyton mentagrophytes, and T. rubrum are informed, and aqueous-extracts acute oral toxicity in mice. Major secondary metabolites in V. carolina extracts are isolated by conventional phytochemical methods, which consist of three terpenoids and four phenolics. Their contents are determined by chromatography in different samples from dissimilar locations. The results indicate that ursolic acid, hispidulin, verbena line, hastatoside, verbascoside, hispidulin 7-O-β-D-glucuronopyranoside, and pectolinaringenin-7-O-α-D-glucuronopyranoside are the main constituents, with verbascoside being the most abundant and significant antioxidant activity in reactive oxygen species (ROS). Hispidulin is the only active compound vs. T. mentagrophytes and T. rubrum. The aqueous extract shows no significant 2toxicity. Mentha comprises several aromatic species, which are cultivated world-over because of their distinct aroma and commercial value. In addition to traditional food flavoring uses, Mentha spp. are well recognized for their folk medicinal services, especially to treat cold, fever, digestive, and cardiovascular disorders.
