Texas has experienced a big boom in energy-related activities such as natural gas and crude oil production since 2008. These activities have created large volumes of Over-Weight (OW) truck operations that have adversely affected the longevity of the pavement infrastructures. This was the motivation to devise a framework for the mechanistic characterization of the Pavement Life Reduction (PLR) of the impacted pavements. To achieve this objective, initially, the authors collected the site-specific traffic information by deploying Portable Weight-in-Motion (P-WIM) devices to ten representative energy corridors in the Eagle Ford Shale region. Subsequently, the traffic information associated with the current and pre-energy development era, pavement layers properties from the field Non-Destructive Testing (NDT), as well as the climate information, were then incorporated in the Mechanistic-Empirical pavement design software to determine the PLR associated with the changes in traffic patterns. The analysis results indicated that the reduction of service life was more pronounced for Farm-to-Market (FM) roads, with less robust structural capacity compared to State and US highways.