ABSTRACT
Chronic diseases are one of the serious health concerns that cause the majority of physiological disorders and death worldwide. Among such diseases, metastases or migration of cancer cells are one of the most prevalent and dreadful forms of health complications. Available diagnosis techniques for metastases are often time consuming and expensive, and create a major obstacle for the efficient healthcare management of chronic diseases. Hence, there remains a high demand for developing miniaturized, affordable, rapid, and high-throughput diagnostic devices for the point of care. Owing to its excellent flexibility and efficiency, microfluidics technology offers tremendous potential for delivering advanced and affordable clinical-level diagnostics with lower fluid volume consumption, more compact and high-throughput performance, ease of operation, and much more. In this chapter, we focus on the microfluidics technologies used to identify the essential factors and detection of metastases to develop more improved therapeutic strategies for the management of cancer. Microfluidics devices, which typically require a very low amount of sample, have been advanced to study cancer cell immigration including extravasation and intravasation in response to mechanical, biochemical, and cellular signals.
