ABSTRACT
In general, intracellular antigens are presented by cells in the context of MHC-1 (HLA class I in humans), which binds to CD8 T cells. In the case of nevirapine, the authors were able to show that the skin rash in Brown Norway rats is caused by a reactive benzylic sulfate formed in the skin. To follow are a few of the mechanisms that have been proposed for the mechanism of iDILI; however, there are likely many more pharmacological effects that could lead to the release of DAMPs and have never been considered. A severe genetic defect in BSEP leads to severe cholestatic liver disease and liver failure in infancy. Some drugs have functional groups, such as primary aromatic amines or quinone metabolites, that can redox cycle and have the potential to produce oxidative stress. Many tyrosine kinase inhibitors have been developed for the treatment of cancer.
