ABSTRACT
Early diagnosis and precise treatment of the brain metastasis may lead to the reduction of brain symptoms and may enhance the quality of life and survival for patients. Many factors, including the origin of cancer, associated symptoms, and size/number of metastases, are considered in planning a treatment strategy for the patient. Radiation therapy, chemotherapy, and surgery are the main treatment options for the management of metastatic brain tumors. Available options for radiotherapy include whole-brain radiation therapy (WBRT), hypofractionated stereotactic radiotherapy (SRT), and single-fraction stereotactic radiosurgery (SRS). Early prediction of local failure can potentially permit effective treatment adjustments and improved treatment outcome. In the following sections, the use of biomarkers in general, and radiomics in particular, will be discussed for therapy response prediction and monitoring.
