The percentage of exclusive breastfeeding in Aceh Province in 2013 was 48%. In 2014 it increased to 55%. However, in 2015 it decreased to 53%. The cause of the decline in exclusive breastfeeding is believed to be due to lack of assistance from health workers. Other causes are physical complaints from mothers who are often exhausted at night and other environmental conditions that follow the trend of the use of bottle or infant formula. In accordance with the target report of exclusive breast milk from 71 mothers, the achievement of exclusive breastfeeding was only 21 people (30%). The purpose of this study was to determine the factors that influence the implementation of the achievement of exclusive breastfeeding in the sub-district Kuta Alam, Banda Aceh District. The research design used was an analytic survey with a cross sectional study approach. The population was 702 mothers who had babies and a sample of 106 mothers who had babies aged 6–24 months. The sampling technique used accidental sampling. The research instrument used a questionnaire that was analyzed by univariate, bivariate and multivariate statistics. The results showed that the factors that influence the achievement of exclusive breastfeeding are health conditions (p value = 0.0001), support of health workers (p value = 0.005), social support (p value = 0.004) and knowledge (p value = 0.018), while the most dominant factor affecting the achievement of exclusive breastfeeding was maternal health conditions. Conclusions are expected for breastfeeding mothers to maintain health conditions in order to provide better breastfeeding exclusively to their health babies from 0 to 6 months age.