Background: People with Mental Disorders (PMD) struggle against illness and stigma. The problems are inseparable each other. Mental illness trigger public stigma and internalization of public stigma trigger severe mental illness. Recently, many adolescents experience mental illness and most of them are students. Students with mental illness usually avoid seeking professional’s help because of public stigma. Therefore, school-based anti-stigma interventions are useful to promote both better mental health and academic performance. Aims: This paper explains protocol of the study in developing school-based anti-stigma intervention by exploring Islamic values and cultures. Methods: Guided by precede-proceed model as conceptual framework, the study will use Randomize Control Trials (RCTs) with pre and post-test design by using mixed methods for data collections. In total, 40 respondents will be interviewed by personal interview and FGDs, and about 500 respondents will be surveyed for baseline data to develop anti-stigma interventions. In total 150 respondents will be selected and assigned to two intervention groups and one control groups (50 respondents for each group) to test the effectiveness of interventions (ASI-HA and ASI-IA). The respondents in each group will be selected by multiple random sampling. Established measures will be used to evaluate study interventions at pre and post-test. Qualitative data will be analysed by qualitative content analysis. Quantitative data will be analysed by Pearson Correlation Coefficient (PCC) to evaluate the effect of interventions and linear or logistic regression to predict prospect of outcomes. Discussion: The development of anti-stigma interventions based on Islamic values is essential because stigma is strongly influenced by beliefs and cultures. Using precede-proceed model as conceptual framework give possibility to researchers to explore communities’ ideas and 350predisposing factors of the problems for strengthen the interventions. Therefore, the researchers are very optimistic that the study will produce effective and suitable anti-stigma interventions to reduce public stigma of students toward people with mental disorders.