ABSTRACT
Incorporation of natural bioactive into nanomedicines, their applications, and evaluation have aggressively been put forward during the last couple of decades. The enormous ability of nanocarriers in enhancing the bioavail-ability, targeting, and efficacy of natural molecules have been well documented. Many findings also demonstrate the application of nanosystems in toxicity reduction and lessening of possible side effects of drugs effective targeting and thereby decrease the dose required. However, it should be noted that the conversion of molecules from natural to the nanoscale can display entirely new or significantly altered physicochemical as well as biological properties and may impose some newer risks to the patient. For instance, some drugs that are not crossing biological barriers may surpass them when transformed into nanoparticles, opening up new dimensions to therapeutic strategies specifically for brain delivery. In addition, they may also get into other cellular compartments and undesirably cause a cascade of adverse reactions including genotoxicity. This chapter outlines the suitability of various bioactive loaded nanocarriers in therapeutics, their toxicity, and regulatory considerations.
