ABSTRACT
Cancer has recently become one of the prominent reasons for human mortality. Since ages, humans have used natural products to prevent illnesses and this hints us that bioactive compounds are one of the best alternative sources which can be employed in the prevention and treatment of various kinds of diseases including cancer. Resveratrol, chemically known as 3,4,′5-trihydroxytrans-stilbene, is a non-flavonoid polyphenol phytoalexin that naturally occurs in various species of plants, including peanuts, grapes, pines, and berries. It has been used since ages in Chinese and Japanese traditional medicine to treat inflammation, headaches, cancers, and amenorrhea. There are several reports of nanoformulations loaded with resveratrol has potential anticancer activity including but not limited to cancer of stomach, prostate, ovaries, alimentary canal, and breast. The nanoformulation of resveratrol has also enhanced its bioavailability in humans. The stability can be adjusted using several natural polymers, such as gelatin, PEG, and PLGA, alone or in combination with synthetic polymers, like chitosan (CS) and casein. Further studies are required to establish it as a potent clinical anticancer agent.
