According to the American College of Rheumatology, conventional medicines have limited effectiveness and are highly toxic. Therefore, 60%-90% concentrate on complementary and alternative medicine and people are dissatisfied with the available therapies. Herbs have enormous potential that are not often seen in synthetic drugs of large structural complexity. Different plant constituents, including terpenoids, flavonoids, fatty acids, steroids, have investigated the anti-rheumatic action. These all target different inflammatory mediators such as nitric oxide (NO), cytokines, chemical substances, conformity molecules, NF-I43, LLOX, and arachidonic acid (AA). They often target various inflammatory mediators. The text presented details on the phytoconstituents based on targeted action on inflammatory biomarkers.