ABSTRACT
Medicinal plants exhibited anti-diabetic activities only in the situations when the plants can rejuvenate the pancreatic tissues function by ameliorating insulin secretion or suppressing glucose absorption in intestinal parts or alleviating insulin-dependent metabolic activities. The effect of protein tyrosine phosphatase 1B on the metabolic arm of the insulin signalling pathway is thought to be mediated upstream of phosphatidylinositol 3-kinase. Phytotherapy for diabetes management has been adopted globally since a long time. Diabetes couldn’t be cured completely but blood glucose level can be controlled by injecting insulin for type 1 diabetes mellitus and through oral medication in case of type 2 diabetes mellitus. With the intervention of Aloe vera, significant reduction was observed in blood glucose of diabetic patients. The in vivo studies demonstrated that Andrographis paniculata extracts significantly reduced peak blood glucose and area under curve in diabetic rats when challenged with oral administration of starch and sucrose.
