ABSTRACT
Currently, the medical field kept their step in nanotechnology which employs the nanoparticles for treating the diseases. The study highlighted the use of nanotechnology in the virus aqueous extracts from the medicinal plants and their effect against herpes virus. Aqueous extract of Punica granatum (P. granatum) (Peels, Juice), Camellia sinensis (C. sinensis), Nilavembu Kudineer Chooranam (NKC), and Acalypha indica (A. indica). Three different nanoparticles (NP) such as silver, gold, and bimetallic were synthesized from the above aqueous extracts and characterized. Anti-HSV (both 1 and 2) activities of these nanoparticles were done by CPE assay. Toxicity of the extracts was determined by MTT assay. Among the tested nanoparticles P. granatum peels silver NP (PgPSNP) exhibiting a potent anti-HSV activity followed by P. granatum juice silver NP > C. sinensis Silver NP > NKC Silver NP > A. indica silver NP. Neither bimetallic nor gold NP exhibited significant anti-HSV activity. Except P. granatum other extracts showed more toxicity. This study indicated that P. granatum peels silver NP (PgPSNP) showed the maximum anti-HSV activity besides its minimal toxicity observed. Thus, PgPSNP is a novel anti-HSV drug which is worth pursuing.
