ABSTRACT
Cancer is one of the most deadly diseases that have affected mankind. After cardiac diseases, it is known to be the next demon that caused mortality 108among millions of people. Heat shock protein 90 (Hsp90) is a homodimer polypeptide, where each monomer’s N, M, and C domain is conserved. Hsp90 is over-expressed in cancer cells (more than 90%) in association with the co-chaperones along with associated client proteins (Met, EGFR, Akt, Her2, and c-Raf) which are responsible towards the chemotherapeutic resistance. Globally, scientists tried to find strategies for the management of cancer by exploring hidden natural products and rationally developing drugs by systematically thoughtful insights into the biological targets. This chapter highlights the plausible functions of a new biological target, Hsp90 in the proliferation of cancer and its management by chalcone based small ligands. The encouraging results of these small molecules at preclinical stages in modulating the biological target in multiple oncogenic pathways have certainly attracted pharmaceutical exerts for better optimization, the establishment of an accurate structure-activity-relationships, and superior chemotherapeutic applications.
